Food packaging serves important functions in protecting, transporting, and educating consumers on the food they enclose. However, studies indicate that some food packaging materials consists of toxic chemicals that migrate into the food and compromise both the safety and quality of food they contain. To ensure public safety governments have established regulations that require compliance and migration testing for food packaging material. However, current standards for compliance and overall migration (OM) testing may not adequately account for nuances that occur with different technologies food packaging materials are bound to encounter including microwave heating. The objective of this study was to determine the effect of microwave heating on OM from four different food containers types labeled for household use in the US, into four types of food simulants (H20, 10% EtOH, 50% EtOH and 95% EtOH) under normal use conditions with microwave ovens. The extent of migration was gravimetrically determined in accordance with EN 1186-9 and further analysis was conducted using HPLC-UV. The results of the study show that migration increased when containers were microwaved, and the extent of migration was dependent on the type of food container and food simulant used. When compared to controls, microwaving containers caused significantly higher amounts of chemicals to migrate out into food simulants. Highest migration occurred with food simulant 95% ethanol in silicone containers with an average OM value of 320 _ 52.27 mg/kg of simulant compared to the non-microwaved control with average OM values of 134_ 50.42 mg/kg. Additionally, the use of lids while microwaving increased the amount of OM in 69% of containers tested when 95% EtOH was used as food simulant. Results from HPLC-UV analysis showed the highest number of peaks and the largest peak intensity for Tritan samples exposed to 95% EtOH. The OM values for some silicone food containers were significantly above the recommended 60 mg/kg of simulant set by the EU. This highlights the need for more rigorous migration and toxicological testing before food containers are released into the marketplace to ensure food safety and quality.