Convection Enhanced Drug Delivery for the Treatment of Brain Gliomas
Loading...
No Access Until
Permanent Link(s)
Collections
Other Titles
Abstract
Malignant brain gliomas are almost always fatal, with a five year survival rate of only 3%. This is due in part to the difficulty of treating tumors chemically or surgically. They are often deep within the brain, where drugs cannot easily diffusive due to the blood-brain barrier and where surgery could be deadly. Emerging techniques for improved treatment include direct infusion of treatment drugs, like Paclitaxel, into the tumor in a procedure known as convection-enhanced drug delivery. These procedures require days of carefully monitored infusion to ensure tumor destruction while preserving surrounding tissue. To better understand the drug distribution and dosing options for different tumor sizes without dangerous medical tests, we have modeled the drug distribution within the tumor and surrounding tissue computationally. The model shows drug distributions consistent with current clinical results after a five day procedure. This model could now be used to better define dosing levels and procedure parameters to maximize tumor removal while preserving healthy tissue in individually unique cases.
Journal / Series
BEE 4530 Projects
Volume & Issue
Description
Sponsorship
Date Issued
2009-05-08T13:49:21Z
Publisher
Keywords
Drug Delivery; Brian Gliomas
Location
Effective Date
Expiration Date
Sector
Employer
Union
Union Local
NAICS
Number of Workers
Committee Chair
Committee Co-Chair
Committee Member
Degree Discipline
Degree Name
Degree Level
Related Version
Related DOI
Related To
Related Part
Based on Related Item
Has Other Format(s)
Part of Related Item
Related To
Related Publication(s)
Link(s) to Related Publication(s)
References
Link(s) to Reference(s)
Previously Published As
Government Document
ISBN
ISMN
ISSN
Other Identifiers
Rights
Rights URI
Types
term paper