eCommons

 

Effect of 5HT-modulated bulbar processing on cortical odor responses in awake-behaving rats

Other Titles

Abstract

The sense of smell is important for survival of many species with respect to finding food and shelter, avoiding danger and interacting with conspecifics. Neuromodulators such as acetylcholine, dopamine, noradrenaline and serotonin can act broadly on brain networks to adjust processing to diverse situations and behavioral needs. In this respect, the present study investigates the impact of serotonin (5HT) manipulation within the olfactory bulb (OB) on neural activity in response to odor stimuli in adult Long Evans Hooded rats. 5HT modulation of olfactory processing has not been studied extensively. We ask to what extend 5HT modulation of early olfactory processing in the olfactory bulb affects cortical responses to odorants. Towards this goal, we manipulated 5HT action in the olfactory bulb via intracerebral infusions of 5HT in rats Our results demonstrate that 5HT significantly increased spontaneous firing rates in both the OB and PC as well as enhanced odor sensitivity of cortical neurons. These findings underscore the importance of 5HT in modulating neural activity within the olfactory pathway, shedding light on the mechanisms underlying odor processing and sensitivity.

Journal / Series

Volume & Issue

Description

Sponsorship

Date Issued

2024-09-18

Publisher

Keywords

Serotonin (5HT); Olfactory bulb; Odar processing; Piriform cortex

Location

Effective Date

Expiration Date

Sector

Employer

Union

Union Local

NAICS

Number of Workers

Committee Chair

Committee Co-Chair

Committee Member

Degree Discipline

Degree Name

Degree Level

Related Version

Related DOI

Related To

Related Part

Based on Related Item

Has Other Format(s)

Part of Related Item

Related To

Related Publication(s)

Link(s) to Related Publication(s)

References

Link(s) to Reference(s)

Previously Published As

Government Document

ISBN

ISMN

ISSN

Other Identifiers

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International

Types

dissertation or thesis

Accessibility Feature

alternative text

Accessibility Hazard

none

Accessibility Summary

Link(s) to Catalog Record