A 17-month old, castrated male, domestic shorthaired cat, presented for a 6-week history of whole body, generalized tremors, which had developed suddenly and were non-progressive. He had no history of exposure to toxins. His tremors were most pronounced in his head and worsened when he was stressed or excited. He had jerky, erratic eye movements, which were thought to be another manifestation of his tremor disorder. The cat's neuroanatomic localization was a diffuse central nervous system disorder. CBC and Chemistry panel results ruled out extraneural causes for the tremors. Serologic tests for infectious diseases were negative. No significant abnormalities were appreciated on CT scan or CSF analysis. Muscle and nerve biopsies were normal. Because diagnostic tests and history failed to reveal an inflammatory, infectious, or toxic cause for tremors and because his signs were consistent with a steroid responsive tremor syndrome seen in dogs, he was treated with immunosuppressive doses of prednisone. His condition improved dramatically within a few days and full recovery was reached within 2 weeks.