Canine immune-mediated hemolytic anemia : presentation and treatment
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Abstract
Canine immune mediated hemolytic anemia (IMHA) is an autoimmune disease
characterized by the increased destruction of red blood cells by autoantibodies. A type
two hypersensitivity reaction, it can be primary or secondary in nature. Most cases are
primary (idiopathic) but secondary IMHA can occur with concurrent infection, such as
with the blood parasites (Ehrlichia and Babesia) or leptospirosis, with inflammation or
immune mediated processes such as systemic lupus erythematosus or with lymphoid
malignancies. Viral infection can also predispose an animal to IMHA, in particular
parvovirus and distemper. Treatment of IMHA centers on finding the causative agent, in
the case of secondary disease, and on immunosuppressive therapy with drugs such as
corticosteroids, cyclosporine, azathioprine and cyclophosphamide. The short-term
prognosis for dogs with IMHA is guarded due to the multiple complications inherent in
the acute stages of the disease. If an animal survives acute disease the long term
prognosis is fair. Dogs frequently experience relapse and may become refractory to
previous therapies with each relapse. This study centers on the case of Scooter, an English bulldog, who was diagnosed at Cornell University's Hospital for Animals
with IMHA in June of 2002.
Journal / Series
Senior seminar paper
Seminar SF610.1 2003 G66
Seminar SF610.1 2003 G66
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Description
Senior seminar (D.V.M.) -- Cornell University, 2003.
Includes bibliographical references (leaves 11-12).
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Advisor: Dr. Tristan Weinkle /
Clinicians: Dr. Richard Goldstein, Dr. Stephen Barr, Dr. Tristan Weinkle
Date Issued
2002-09-04
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Keywords
Dogs -- Diseases -- Treatment -- Case studies
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term paper