"Max", a 5 year old male castrated ferret was presented to the Cornell University Hospital for Animals (CUHA) Exotics Service with a one day history of lethargy and "lump" on his abdomen the morning of presentation and brought him in to the referring veterinarian (rDVM). The rDVM palpated a large, turgid urinary bladder, and referred him to Cornell. Cystocentesis and urinalysis revealed a presumptive urinary tract infection secondary to urinary retention. Abdominal ultrasound showed bilateral adrenomegaly, prostatomegaly, an abnormal urinary bladder, bilateral pyelectasia, and a distended cranial urethra. Bloodwork showed an array of electrolyte abnormalities consistent with urinary retention such as hyperkalemia, hypocalcemia, hyperphosphatemia and azotemia. Based on these findings a diagnosis of sex hormone hyperadrenocorticism with secondary prostatic hyperplasia and resultant urinary tract obstruction was made. A urinary catheter was placed and Max was given a dose of leuprolide acetate, a GnRH agonist. He was given supportive care, including intravenous fluids and pain medications over the course of 4 days, during which time he developed bruxism and a post-obstructive diuresis. Bruxism was assumed to be a sign of a developing gastric ulcer and Max was put on famotidine. The post-obstructive diuresis was treated by altering fluid therapy to correct for electrolyte imbalances. When Max was stabilized and able to urinate on his own, his urinary catheter was removed and he was sent home in the care of his owners, who opted to continue medical management of Max's adrenal disease with the rDVM.