The gut microbiome of TLR5-/- mice displays increased motility, which can be inhibited by anti-flagellin antibodies

dc.contributor.author	Cullender, Tyler
dc.date.accessioned	2013-03-07T20:33:22Z
dc.date.available	2018-02-05T07:00:47Z
dc.date.issued	2013-02-15
dc.description.abstract	TLR5-/- mice have an innate immune deficiency in recognizing bacterial flagellin, which results in increased flagellin expression by the microbiota and decreased anti-flagellin antibodies produced by the host. Here we show that the gut microbiome of TLR5-/- mice displays increased motility compared to wild-type controls (WT). The addition of antibodies with specificity to the flagellin protein of Roseburia hominis (Fla2) and Escherichia coli (FliC) decreased motility in bacteria from both mouse types within one hour.	en_US
dc.identifier.uri	https://hdl.handle.net/1813/31548
dc.language.iso	en_US	en_US
dc.subject	flagellin	en_US
dc.subject	flagella	en_US
dc.subject	IgA	en_US
dc.subject	microbiome	en_US
dc.subject	gut	en_US
dc.subject	mouse	en_US
dc.subject	TLR5	en_US
dc.title	The gut microbiome of TLR5-/- mice displays increased motility, which can be inhibited by anti-flagellin antibodies	en_US
dc.type	video/moving image	en_US