An eight-year-old male castrated Golden Retriever presented to the Cornell University Hospital for Animals Ophthalmology Service for sudden vision impairment that began approximately two weeks prior to presentation. On ophthalmologic exam, trace flare was seen in the anterior chambers of both eyes (OU) and inferior bullous retinal detachments with additional multifocal areas of retinal detachment were present OU. These signs were consistent with a diagnosis of panuveitis OU. To identify an underlying cause for the patient’s uveitis, a full work-up was performed. Based on the patient’s marked hyperglobulinemia evident on a serum biochemistry panel and the presence of aggressive bone lesions on the left 5th, 9th, and 10th ribs on thoracic radiographs, a presumptive diagnosis of multiple myeloma was made. A follow-up with Cornell’s Oncology Service was highly recommended, and treatment for the patient’s uveitis was initiated. This case report will describe pertinent clinical findings and possible differential diagnoses in a dog with uveitis. Further, other occurrences of multiple myeloma presenting as a primary ocular pathology will be discussed.