eCommons

 

Genetic Basis of Rotenone-induced Parkinson’s Disease Model in Drosophila melanogaster

Other Titles

Abstract

Parkinson’s disease (PD) is a neurological disorder that exists in sporadic and familial forms and causes the death of dopamine-producing neurons in humans. Rotenone, a pesticide, can be used to induce a model of sporadic PD in Drosophila melanogaster. The genetic pathogenesis of PD is still being determined in both humans and D. melanogaster. Conducting a genome-wide association study on the genetic variation of D. melanogaster from the Drosophila Genetic Reference Panel (DGRP) with rotenone-induced PD uncovered a set of candidate genes that alter sensitivity to the pesticide. Many of these genes point to possibly important roles of natural variation in the Fibroblast Growth Factor (FGF) Pathway and microtubule synthesis. As microtubule is central to the transport of dopamine in D. melanogaster, these findings suggest a possible explanation of sporadic PD in humans based on genetic and environmental interactions.

Journal / Series

Volume & Issue

Description

Sponsorship

Date Issued

2020-06

Publisher

Keywords

Biological sciences honors program; rotenone; Parkinson’s; microtubule

Location

Effective Date

Expiration Date

Sector

Employer

Union

Union Local

NAICS

Number of Workers

Committee Chair

Clark, Andrew G.

Committee Co-Chair

Committee Member

Degree Discipline

Biological Sciences

Degree Name

B.A., Biological Sciences

Degree Level

Bachelor of Arts

Related Version

Related DOI

Related To

Related Part

Based on Related Item

Has Other Format(s)

Part of Related Item

Related To

Related Publication(s)

Link(s) to Related Publication(s)

References

Link(s) to Reference(s)

Previously Published As

Government Document

ISBN

ISMN

ISSN

Other Identifiers

Rights

Rights URI

Types

dissertation or thesis

Accessibility Feature

Accessibility Hazard

Accessibility Summary

Link(s) to Catalog Record