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dc.contributor.authorHall, Tara
dc.date.accessioned2019-10-15T15:30:45Z
dc.date.available2021-06-05T06:00:46Z
dc.date.issued2019-05-30
dc.identifier.otherHall_cornell_0058O_10500
dc.identifier.otherhttp://dissertations.umi.com/cornell:10500
dc.identifier.otherbibid: 11050364
dc.identifier.urihttps://hdl.handle.net/1813/67382
dc.description.abstractRecent studies in the Tumbar Laboratory have identified heterogenous domains in the interfollicular epidermis of skin based on gene expression patterns. These heterogenous domains are inhabited by two types of stem cells; slow cycling label retaining cells (LRCs) and fast cycling non-LRCs. My work has focused on identifying genetic markers for the slow cycling LRCs. I critically investigated previous microarray data obtained from LRCs and nonLRC analysis to identify genes that were preferentially expressed in LRC domains. Two new potential markers of epidermal LRCs have been identified, however, based on immunofluorescent studies, these two genes were not found to overlap with the strongest LRCs. Instead they overlapped with LRCs that had partially reduced label. These gene expression domains are also spatiotemporally dynamic. Therefore, these midrange LRCs may indicate a third epidermal stem cell population. This opens the way to further functional studies to elucidate the role of gene expression heterogeneity in the epidermis.
dc.language.isoen_US
dc.subjectepidermis
dc.subjectCellular biology
dc.subjectBiology
dc.subjectHeterogeneity
dc.subjectMolecular biology
dc.subjectGene expression
dc.subjectStem Cell
dc.titleCHARACTERIZING MOLECULAR HETEROGENEITY OF STEM CELL EPIDERMAL LINEAGES
dc.typedissertation or thesis
thesis.degree.disciplineBiomedical and Biological Sciences
thesis.degree.grantorCornell University
thesis.degree.levelMaster of Science
thesis.degree.nameM.S., Biomedical and Biological Sciences
dc.contributor.chairTumbar, Tudorita
dc.contributor.committeeMemberNikitin, Alexander
dc.contributor.committeeMemberBuchon, Nicolas S.
dc.contributor.committeeMemberWhite, Andrew C
dcterms.licensehttps://hdl.handle.net/1813/59810
dc.identifier.doihttps://doi.org/10.7298/brq0-fv35


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