Risk Of Congenital Malformations Following In Utero Exposure To Inhaled Corticosteroids In Early Pregnancy In Controlled Versus Uncontrolled Asthmatics

Abstract

Problem: Asthma requiring daily medication is a major medical condition in nearly 3-8% of pregnancies. Currently, there are no medications deemed safe by the FDA for pregnancy. The effects of many medications are still unknown. Purpose: To identify the effects on normal fetal development of inhaled corticosteroid use during pregnancy. To identify the role asthma control has on fetal development. Research Questions: Does inhaled corticosteroid use during pregnancy cause more congenital anomalies in infants of uncontrolled asthmatics than those of controlled asthmatics? Methods: A prospective cohort study will follow women from their first prenatal visit through the end of the neonatal period. They will be asked to complete surveys regarding asthma symptoms and treatment. Neonates will be assessed on days 1 and 28 of postnatal life to assess for any congenital malformations. Outcomes: A literature review was performed and a total of thirteen articles were chosen. These articles highlighted the various effects of in utero exposure to corticosteroids when taken for maternal asthma. Benefit: This prospective cohort study will help clinicians better understand the effects of treating asthma during pregnancy by giving a better understanding of the potential dangers of uncontrolled asthma on fetal development.