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dc.contributor.authorLiu, Jinjing
dc.date.accessioned2018-10-23T13:34:51Z
dc.date.available2018-10-23T13:34:51Z
dc.date.issued2018-08-30
dc.identifier.otherLiu_cornell_0058O_10356
dc.identifier.otherhttp://dissertations.umi.com/cornell:10356
dc.identifier.otherbibid: 10489774
dc.identifier.urihttps://hdl.handle.net/1813/59678
dc.description.abstractFusobacterium nucleatum is a Gram-negative anaerobic bacterium prevalent in the human oral cavity. This oral commensal bacterium has been shown as the main contributor for many dental diseases, including periodontitis and gingivitis. Recently, evidence has verifying the linkage between F. nucleatum and carcinogenesis of colorectal cancer (CRC). Outer membrane vesicles (OMVs) are naturally occurring metabolic byproducts secreted by Gram-negative bacteria, and contain highly antigenic LPS and outer membrane protein residues. Due to its antigen containing and non-self-replicated properties, OMVs are emerging as a powerful platform for vaccine design and delivery. We speculated the OMVs from F. nucleatum might contain antigens able to elicit effective immune response. In this study, we identified 98 proteins from purified OMVs of F. nucleatum through proteomic studies. In silica analysis indicates the non-replicative OMVs of F. nucleatum contain a variety of antigenic virulence factors and may play a critical role in vaccine design.
dc.language.isoen_US
dc.subjectouter membrane vesicles
dc.subjectproteome
dc.subjectImmunology
dc.subjectvaccine
dc.subjectMicrobiology
dc.subjectBioinformatics
dc.subjectFusobacterium nucleatum
dc.titlePROTEOMIC CHARACTERIZATION OF FUSOBACTERIUM NUCLEATUM OUTER MEMBRANE VESICLES
dc.typedissertation or thesis
thesis.degree.disciplineAnimal Science
thesis.degree.grantorCornell University
thesis.degree.levelMaster of Science
thesis.degree.nameM.S., Animal Science
dc.contributor.chairChang, Yung-Fu
dc.contributor.committeeMemberMohammed, Hussni Omar
dc.contributor.committeeMemberLei, Xingen
dcterms.licensehttps://hdl.handle.net/1813/59810
dc.identifier.doihttps://doi.org/10.7298/X4GH9G6P


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