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dc.contributor.authorIm, Joo Hyun
dc.date.accessioned2018-10-23T13:22:19Z
dc.date.issued2018-05-30
dc.identifier.otherIm_cornellgrad_0058F_10812
dc.identifier.otherhttp://dissertations.umi.com/cornellgrad:10812
dc.identifier.otherbibid: 10489461
dc.identifier.urihttps://hdl.handle.net/1813/59376
dc.description.abstractInsects maintain a close relationship with microbes in the environment. This interaction has led to the development of the innate immune system, which is responsible for defending the host from a wide range of pathogens. As pathogens evolve to compromise host immunity, immune genes rapidly counter-evolve. In this dissertation, I present studies that answer how the innate immune system of Drosophila responds to a variety of pathogens and how host-pathogen interactions may have shaped the evolution of host cellular immunity. In Chapter 2, I explore how an arms race between Drosophila and its pathogens may have led to selective sweeps and adaptive evolution in the Drosophila cellular immune system. In Chapter 3, I present work on how host responses to infection with various bacteria are crucial in host survival and homeostasis. In Chapter 4, I investigate the role of genes that are expressed in a coordinated manner upon infection and identify key genes for future functional genetic studies. Altogether, these studies provide a clearer mechanistic and population genetic understanding of host-pathogen interactions and Drosophila immunity.
dc.language.isoen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGenetics
dc.subjectPopulation genetics
dc.subjectDrosophila
dc.subjectFunctional genetics
dc.subjectInnate immunity
dc.titleFunctional and Population Genetics of Drosophila Innate Immunity
dc.typedissertation or thesis
dc.description.embargo2020-06-04
thesis.degree.disciplineEntomology
thesis.degree.grantorCornell University
thesis.degree.levelDoctor of Philosophy
thesis.degree.namePh. D., Entomology
dc.contributor.chairLazzaro, Brian
dc.contributor.committeeMemberClark, Andrew
dc.contributor.committeeMemberDanko, Charles G.
dcterms.licensehttps://hdl.handle.net/1813/59810
dc.identifier.doihttps://doi.org/10.7298/X4F18WZ0


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