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Department of Medicine
Optimization of lead compounds into on-demand, non-hormonal contraceptives: leveraging a public-private drug discovery institute collaboration (Oxford Academic, 2020-04)Efforts to develop new male or female non-hormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; ...
Rising to the Challenge of COVID-19: Advice for Pulmonary and Critical Care and an Agenda for Research (American Thoracic Society, 2020-05)
CIC is a Critical Regulator of Neuronal Differentiation (American Society for Clinical Investigation, 2020-03)Capicua (CIC), a member of the high mobility group (HMG)-box superfamily of transcriptional repressors, is frequently mutated in human oligodendrogliomas. But its function in brain development and tumorigenesis remains ...
Central lateral thalamic nucleus stimulation awakens the cortex via modulation of cross-regional, laminar specific activity during general anesthesia (Elsevier, 2020-04-08)Experiments identify cortical layer specific effects during induced arousal from general anesthesia. In this issue of Neuron, Redinbaugh et al. (2020) find evidence that central lateral thalamic nucleus electrical stimulation ...
Adding a Medicine to WHO Model List of Essential Medicines (Nature Publishing Group; Clinical Pharmacology & Therapeutics, 2009-03)Although the concept of essential medicines is not new, the processes that lead to placement of these medicines on the World Health Organization Model List of Essential Medicines are not well understood. Here, we describe ...