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Weill Cornell Theses and Dissertations
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High Throughput Genetics And Characterization Of An RNA Arbovirus, Sindbis Virus, Using Accurate Next-Generation Sequencing Of Viral Evolution And RNA Enrichment
(2020-05-20)The goal of these studies was to investigate Sindbis virus adaptation to various infection bottlenecks and utilize the dynamics of minor variants to study viral genetics in a high-throughput manner. During infection an RNA ... -
Decoding Chromatin Accessibility Programs In Cancer
(2019)Chromatin accessibility plays an important role in defining cell identity and phenotype. With the emergence of novel methods like ATAC-seq, a sequencing method that maps regions of open chromatin and enables the computational ... -
Dna Replication And Transcription In The C. Elegans Embryo
(2019)Animal embryogenesis represents a cascade of genetically encoded events that transform a single-celled zygote, composed of cytoplasm and nuclei from two haploid gametes, into a fully formed organism. The “totipotent” zygote ... -
Statistical Models For The Function And Evolution Of Cis-Regulatory Elements In Mammals
(2019)Precise gene regulation is essential for a wide variety of transient, developmental, and homeostatic processes. The majority of gene regulation is mediated by cis-regulatory elements, both distal (enhancers), and proximal ... -
Representation Learning On Sequential Medical Data
(2019)The way we do medicine is undergoing a revolution driven by technology. As the modern drive to record, share, and analyse data sweeps across society, healthcare lies squarely in its path. Data generated by every-day clinical ... -
Consequences of Pericentromeric DNA Hypomethylation: Lessons From an Animal Model of ICF Syndrome
(2019)The modified base, 5-methylcytosine (5mC) is enriched at repetitive DNA sequences including satellite repeats that surround chromosome centromeres. These centromeric and pericentromeric satellite repeats are important for ... -
A Novel Optical Dynamic Clamp Platform Using Ipsc-Derived Cardiomyocytes For Drug Screening
(2019)iPSC-derived cardiomyocytes (iPSC-CMs) are a potentially advantageous platform for drug screening because they provide a renewable source of human cardiomyocytes and can be patient specific. One obstacle to their implementation ... -
Applications Of Mass Spectrometry-Based Metabolomics To Address Biomedical Problems
(2019)The cadre of small molecule metabolites in a cell, aka the “metabolome,” is the final output of the genome and ultimate determinant of cell phenotype (DNA ? RNA ? protein ? metabolite ? phenotype). In addition to a genetic ... -
Ethanol (Etoh)-Mediated Differentiation Of Embryonic Stem Cells Via Retinoic Acid (Ra)-Retinoic Acid Receptor-Gamma (Rar?) Signaling
(2019)Ethanol (EtOH) is a teratogen, but the mechanisms by which EtOH exerts its teratogenic effects aren’t fully understood. Vitamin A (all-trans retinol/ROL) can be oxidized to all-trans-retinoic acid (RA), which plays a ... -
Characterizing Notch1 Singaling Regulation And Amyloid Beta Cleavage
(2019)Gamma secretase cleaves numerous substrates that regulate a variety of cellular processes. The involvement of Gamma secretase in so many different signaling systems makes it a challenging enzyme to target without toxic ...
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