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  Dna Replication And Transcription In The C. Elegans Embryo 

  Bellush, James (2019)

  Animal embryogenesis represents a cascade of genetically encoded events that transform a single-celled zygote, composed of cytoplasm and nuclei from two haploid gametes, into a fully formed organism. The “totipotent” zygote ...
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  Decoding Chromatin Accessibility Programs In Cancer 

  Chhangawala, Sagar (2019)

  Chromatin accessibility plays an important role in defining cell identity and phenotype. With the emergence of novel methods like ATAC-seq, a sequencing method that maps regions of open chromatin and enables the computational ...
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  Representation Learning On Sequential Medical Data 

  Hyland, Stephanie (2019)

  The way we do medicine is undergoing a revolution driven by technology. As the modern drive to record, share, and analyse data sweeps across society, healthcare lies squarely in its path. Data generated by every-day clinical ...
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  Statistical Models For The Function And Evolution Of Cis-Regulatory Elements In Mammals 

  Dukler, Noah (2019)

  Precise gene regulation is essential for a wide variety of transient, developmental, and homeostatic processes. The majority of gene regulation is mediated by cis-regulatory elements, both distal (enhancers), and proximal ...
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  A Novel Optical Dynamic Clamp Platform Using Ipsc-Derived Cardiomyocytes For Drug Screening 

  Quach, Bonnie (2019)

  iPSC-derived cardiomyocytes (iPSC-CMs) are a potentially advantageous platform for drug screening because they provide a renewable source of human cardiomyocytes and can be patient specific. One obstacle to their implementation ...

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