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dc.contributor.advisorLinster, Christiane
dc.contributor.authorJayakymar, Sachidhanand
dc.description.abstractThe aim of this project is to quantify the olfactory dysfunctions associated with Parkinson’s Disease in a mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model. Parkinson’s Disease, like many neurodegenerative diseases, gives rise to olfactory deficits during the early nonmotor stages of disease development. The MPTP neurotoxin model is a common method to study this early state progression due to the slow, realistic rate of neuronal degradation it causes throughout the brain. Even with the presence of such a model, a focus on the predominant motor aspects of the disease has left these smell losses inadequately explored from a neurochemical and behavioral level. Thus, the two objectives of this study are: to assess olfactory deficits in the MPTP model through discrimination/duration tests, and to correlate these behavioral results to previously observed changes of dopamine (DA) levels in the striatum. These results will help connect the behavioral progression of PD with the existing knowledge of olfactory processing networks. Beyond learning about the mechanisms themselves, the eventual hope is that such knowledge can be applied to the patient setting to develop a reliable disease marker before the onset of conventional PD symptoms.
dc.subjectBiological sciences honors program; Olfaction; Parkinson disorder; pharmacology; dopamine 
dc.titleNeuromodulator and olfaction deficits in an MPTP mouse model of Parkinson's Disease
dc.typedissertation or thesis Sciences of Arts of Biological Sciences

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