Browsing Cornell University Graduate School by Subject "P-glycoprotein"
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(2015-08-17)Drug development for the central nervous system (CNS) has struggled to reach clinical approval. One reason many drugs do not advance into clinical applications is their low uptake in the CNS due to the blood brain barrier ...
QUINIDINE-CONTAINING POLYMERS FOR REVERSAL OF P-GLYCOPROTEIN MEDIATED DRUG EFFLUX IN MULTIDRUG RESISTANT CANCERS (2020-08)P-glycoprotein (P-gp) is a membrane protein innately expressed at barrier sites in the body, including the blood-brain barrier, intestines, and many different cancers. P-gp binds small molecules, termed “substrates,” that ...