The objective of this research was to understand the ergonomic impact of multi-touch screen systems as well as space planning needs for using such systems in both single person and collaborative work environment. The impact of screen orientations and scenarios of use on the participants' head, neck and trunk postures when interacting with a simulated large multi-touch screen was analyzed based on the three dimensional kinematic data obtained through a video-based motion capture system. Sixteen participants took part in the experiment and performed three simulated tasks for three screen orientations (horizontal/ vertical/ self-adjusted) and two scenarios (single person/ collaboration). Some kinematic concerns for using the simulated multi-touch screen were identified in this study. The vertical orientation was the best orientation in terms of head, neck and trunk kinematics. For horizontal orientation, in general mean trunk flexion range exceeded 20 degrees in the collaboration scenario and mean trunk axial rotation range was around 17 degrees. For self-adjusted orientation, trunk flexion and trunk axial rotation remained within an acceptable range; meanwhile it could offer more choices for the users. The participants' preferred screen tilted angles were analyzed and two possible fixed screen adjustments were suggested. Basic space planning needs were analyzed for interacting with the simulated multi-touch screen across screen orientations and single person/ collaborative use.