The gut microbiome of TLR5-/- mice displays increased motility, which can be inhibited by anti-flagellin antibodies
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TLR5-/- mice have an innate immune deficiency in recognizing bacterial flagellin, which results in increased flagellin expression by the microbiota and decreased anti-flagellin antibodies produced by the host. Here we show that the gut microbiome of TLR5-/- mice displays increased motility compared to wild-type controls (WT). The addition of antibodies with specificity to the flagellin protein of Roseburia hominis (Fla2) and Escherichia coli (FliC) decreased motility in bacteria from both mouse types within one hour.
flagellin; flagella; IgA; microbiome; gut; mouse; TLR5