Diabetic ketoacidosis in a mixed breed dog
Zollo, Ann Marie
Diabetic ketoacidosis (DKA), a serious complication of decompensated diabetes mellitus (DM), is associated with considerable morbidity and mortality in veterinary patients as it results in major fluid, electrolyte, and acid-base disturbances and usually occurs with a comorbid process. The pathophysiology of DKA involves a relative or absolute insulin deficiency combined with an increase in circulating counter-regulatory hormones (CRH; such as glucagon, cortisol, epinephrine, and growth hormone) typically arising secondary to a concurrent disease process. The increased CRH:insulin ratio eventually results in hyperglycemia and ketonemia, with subsequent glucosuria and ketonuria. Treatment of DKA is aimed at restoring intravascular volume, reducing hyperglycemia while reversing ketonuria, correcting acid-base and electrolyte imbalances, and managing any concurrent disease processes. Prognosis of DKA is variable in that it is largely dependent on the underlying comorbidity.
Senior seminar paperSeminar SF610.1 2013
Dogs -- Diseases --Case studies