This is a repository of student class project reports for Professor Ashim Datta's BEE 4530/Computer-aided Engineering course. For more details on the course, see http://4530.bee.cornell.edu/.


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  • Still a Threat: Polychlorinated Biphenyl (PCB) Metabolism in Cells & Formation of Cancer-Causing DNA Adducts 

    Chang, Wei-Ann; Taveras, Alwany Angeles; Saadatmand, Bahareh; Gaul, Larissa (2021-05)
    Despite PCBs having been banned from manufacturing processes for decades, polychlorinated biphenyls or PCBs can still enter the environment through various means, such as improper waste disposal methods, and wreak havoc. ...
  • Frostbyte: Multi-Phase Lower Digital Freezing 

    Cooke, Benjamin; Jaicks, John; Kitzinger, Cameron; Sheppard, TJ (2021-05)
    Though frostbite is an affliction that has been commonly known for hundreds of years, its direct effect and dynamics have rarely been studied. With modern technology and an understanding of the human body, tissue freezing ...
  • An Injectable Oxygen and VEGF Releasing Hydrogel for Cardiac Tissue Regeneration 

    Li, Linda; Lubinus, Ariadna; Murundi, Shamanth; Prakash, Gayatri (2021-05)
    The purpose of this study was to determine the design requirements of an injectable fibrin hydrogel as a viable tool in delivering sufficient oxygen (O2) and vascular endothelial growth factor (VEGF) to hypoxic tissue to ...
  • Murdering the Murder Hornet: Heat and CO2 Exchange in a Bee-ball 

    Shack, Jasmine; Yu, Evelyn (Zichen); Yu, Ruoqian Lin; Fang, Ye (2021-05)
    Bee-balling is a defensive technique employed by Japanese honeybees, Apis cerana japonica, against the predatory Asian giant hornet, Vespa mandarinia. Upon recognition of the hornet intruder within the hive, hundreds of ...
  • A Model of Transdermal Drug Delivery through Electroporation 

    Adair, James; Chou, Emily; Metzloff, Matt; Tse, Truman (2021-05)
    Electroporation is a technique that applies high voltage pulses over short time periods, resulting in strong electric fields, to create micropores in cell membranes. When applied to the skin, electroporation causes Joule ...
  • Designing and Optimizing a Protocol for Whole-Ovary Vitrification 

    Scott, Mitchell Tyler; Chen, Dave; Cheng, Evan (2020-05)
    Ovarian tissue cryopreservation (OTC), a process to preserve human ovarian tissue by cooling to subzero temperature without ice formation, has been increasingly studied within the last 15 years. This is due to the growing ...
  • Effect of Fibrotic Layer Formation on Oxygen Delivery to Pancreatic Cells in a (REDACTED) Cell Encapsulation Device 

    BICA, GABRIELLA; CHAN, IRENE; WANG, JEREMY; WOOLF, LILY (2020-05)
    Fibrosis is an immune response that handicaps the effectiveness of biomedical devices for individuals with type 1 diabetes. As an implant becomes encapsulated with connective tissue, forming a fibrotic layer, cells within ...
  • Modeling of Primary Freeze Drying Phase of Lyophilization of Ebola Virus Disease Vaccine 

    Adams, Abby; Flood, Donovan; Ganesan, Sandhya; Koga, Maho (2020-05)
    Lyophilization, or freeze-drying, is a commonly used technique to extend the shelf life and increase the stability of various pharmaceuticals by removing excess water from the product. The process can be energy and ...
  • Effect of Layout and Shape to the Drug Delivery of Intratumoral Implant 

    Xue, Zhengxing; Cai, Yalu; Fuchs, Matthieu (2020-05)
    Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. In 2015, about 90.5 million people had cancer. About 14.1 million new cases occur a year.[1] ...
  • Heat Transfer in Penguin Huddles 

    Karben, Samson; Kim, Glenn; Purwamaska, Ivanakbar; Tormey, Caitlin (2020-05)
    Emperor penguins have several adaptations that allow them to survive the extreme Antarctic winter. Some of these adaptations are behavioral, such as huddling to reduce exposure and preserve body heat. While previous research ...

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