eCommons

 

Design of CMOS Neural Probes Utilizing Micro-coil Magnetic Neurostimulation

Other Titles

Abstract

Neural prostheses that stimulate the neocortex utilizing electrical stimulation via implantable electrodes have been used to treat a wide range of neurological and psychological disorders. However, fundamental limitations of implantable electrodes have limited the prosthesis effectiveness as there remains concerns over their long-term stimulation efficacy and inability to create precise patterns of neural activity. Latest developments in micro-magnetic technology have shown that magnetic stimulation from micro-coil-based neural probes is capable of modulating neural behavior while circumventing the limitations of implantable electrodes. This is due to the induced electric fields from magnetic stimulation being spatially asymmetric, avoiding the simultaneous stimulation of passing axons, as well magnetic fields having high permeability to biological substances, allowing for complete device encapsulation. While these devices have been shown to modulate neural activity in both in vitro and in vivo experiments, the lack of reconfigurable hardware on the probe fixes the location of the neurostimulation sites post-implantation. This works explores how co-designing CMOS circuitry, micro-coil design, and nanofabrication processing can be used to fabricate the next generation of micro-coil-based neural probes, capable of spatially programmable micro-magnetic neurostimulation.

Journal / Series

Volume & Issue

Description

172 pages

Sponsorship

Date Issued

2022-05

Publisher

Keywords

CMOS technology; Micro-magnetic stimulation; Nanofabrication; Neural probe; Neurostimulator

Location

Effective Date

Expiration Date

Sector

Employer

Union

Union Local

NAICS

Number of Workers

Committee Chair

Molnar, Alyosha Christopher

Committee Co-Chair

Committee Member

Apsel, Alyssa B.
Goldberg, Jesse H.

Degree Discipline

Electrical and Computer Engineering

Degree Name

Ph. D., Electrical and Computer Engineering

Degree Level

Doctor of Philosophy

Related Version

Related DOI

Related To

Related Part

Based on Related Item

Has Other Format(s)

Part of Related Item

Related To

Related Publication(s)

Link(s) to Related Publication(s)

References

Link(s) to Reference(s)

Previously Published As

Government Document

ISBN

ISMN

ISSN

Other Identifiers

Rights

Attribution 4.0 International

Types

dissertation or thesis

Accessibility Feature

Accessibility Hazard

Accessibility Summary

Link(s) to Catalog Record