The Fruit Belt is bordered by North Street on the north, Jefferson Street on the east, the Kensington Expressway on the south, and Michigan Street on the west. The Buffalo Niagara Medical Campus (BNMC) lies directly west of the Fruit Belt, across Michigan Street. Historically, the neighborhood was much larger, encompassing the area where the BNMC is now located, and stretching from Main Street in the West to Best Street in the north, and Genesee Street in the east. However, the construction of the Kensington Expressway and the BNMC, as well as other developments in the surrounding area, shrank the neighborhood to its current size.