Nicotine patches are currently used as a transdermal drug delivery method help to people trying to quit smoking. Currently, those trying to quit smoking are encouraged to place the nicotine patch on the outside of the upper arm. This study examined the effect of placing the nicotine patch in different locations on the body. This was accomplished by examining a cylindrical section of skin (epidermal and dermal layers) with a nicotine patch placed on top. Epidermal layers were varied depending on the location of the patch: abdomen, back, ear and buttocks. The results showed that the placement of the patch on the body is relevant and that the epidermal layer of the skin is the biggest barrier to transdermal drug delivery. For faster delivery directly to blood it is useful to use an area of the body with a thin epidermal layer, but for a more time consistent delivery to the blood, a thicker epidermal layer is preferable. http://instruct1.cit.cornell.edu/courses/bee453/secure/student2002/Albuterol/Webpage/