Portal hypertension is exceedingly rare in young animals, and when it does occur is generally associated with hepatic fibrosis, chronic liver injury, cirrhosis, portal vein thromboembolism or obstruction of the hepatic veins. There have been a few cases in dogs characterized by portal hypertension and multiple acquired portosystemic shunts that were due to unique hepatic abnormalities characterized as noncirrhotic portal hypertension and primary portal hypoplasia. The cause of these conditions is unknown, and they seem to be histologically very similar. Here I describe a case of portal hypertension and multiple acquired shunts in a 14 month old Italian Greyhound that appears to be affected by one or both of these conditions.