IN THIS ISSUE: Biophysics and Biotechnology at Cornell /2 (Lynn W. Jelinski) ... Bioremediation of Environmental Pollutants /7 (Eugene L. Madsen) ... The Biological Physics of Cells: Research in the Developmental Resource for Biophysical Imaging Optoelectronics /12 (Watt W. Webb) ... Surrogate Animals for Laboratory Tests /19 (Michael L. Shuler) ... Polyethylene Components for Hip and Knee Replacements (Donald L. Bartel) ... The Multiple-Minima Problem in Protein Folding (Harold A. Sheraga) ... Register /38 ... Faculty Publications /50