(Abstract from full manuscript in Water vol 14, January 2022) Understanding the relationship between topography, hydrological processes, and runoff source areas is essential in engineering design, such as predicting floods and implementing effective watershed management practices. This relationship is not well defined in the highlands with a monsoon climate and needs further study. The objective of this study is to relate topographic position and hydrological response in tropical highlands. The research was conducted in the Debre Mawi watershed in the northwest sub-humid Ethiopian highlands. In the monsoon rain phase of 2017 and 2018, groundwater depth, infiltration rate, and surface runoff were monitored at the upslope, midslope, and downslope positions. Surface runoff rates were measured in farmer fields through distributed V-notch weirs as estimates of positional runoff. Average water table depths were 30 cm deep in the downslope regions and 95 cm in the upslope position. The water table depth affected the steady-state infiltration rate in the rain phase. It was high upslope (350 mm/hr), low midslope (49 mm/hr), and zero downslope. In 2017, the average runoff coefficients were 0.29 for the upslope and midslope and 0.73 downslope. Thus, topographic position affects all aspects of the watershed hydrology in the sub-humid highlands and is critical in determining runoff response.