Hemp based cannabinoids have gained popularity in veterinary medicine due to the potential to treat pain, seizure disorders and dermatological maladies in dogs. Cat owners are also using hemp-based products for arthritis, anxiety and neoplastic disorders with no studies assessing hemp cannabinoids, namely cannabidiol efficacy, for such disorders. The aim of our study was to assess physiological and 24-hr and one-week steady state pharmacokinetic response to a cannabidiol (CBD) and cannabidiolic acid (CBDA) rich hemp in a palatable oral paste. The results of this study suggest that the absorption of those compounds may be superior to oil bases used previously, and show that the acidic forms of cannabinoids appear to be absorbed better than the non-acidic forms. No adverse events related to neurological functions or behavioral alterations, and no clinically significant serum biochemical changes of hepatic and renal functions were observed, further suggesting that short term treatment was safe.