An approximately one year old Jersey heifer was submitted to the Pathology Service of the Cornell Animal Health Diagnostic Center for necropsy in late spring. The heifer was purchased along with a group of heifers from out of state several weeks prior. The owner noted she was ataxic, had several periods of recumbency, and seemed blind just prior to death. No other history about the heifer is known. Gross pathology revealed a severe, chronic, multifocal to coalescing ulcerative glossitis, esophagitis, gastroenteritis, and colitis. Additionally, there was moderate, chronic, multifocal pneumonia and pleuritis as well as a mild multifocal to coalescing hyperkeratotic and exfoliative dermatitis. The major working differential for the ulcerative gastrointestinal lesions was mucosal disease due to Bovine Viral Diarrhea Virus (BVDV). Histopathology confirmed the ulcerations and also showed herniation of crypts into Peyer's patches within the ileum, which has been shown to be characteristic of BVDV. However, all diagnostic tests were negative for BVD.