This study contributes to basic knowledge of the determinants of house value in the United States by examining factors related to demography, time lag, accessibility to amenities, and house value spillovers using spatial data analysis and statistical learning techniques. Household type, education attainment, unemployment rate (and its time lag variable), industry by occupation, median household income (and its time lag variable), accessibility to transportation and spillovers effect are found to be important determinants of house value in core based statistical areas in the United States.