Feline lower urinary tract disease, or FLUTD, refers to any of a series of disorders affecting the feline urinary bladder or urethra. While a variety of etiologies have been associated with lower urinary tract disease, dysuria, pollakiuria, stranguria, hematuria, and peruria are the five clinical signs consistently observed in animals with this disorder. It is estimated that between 1-2% of cats in the United States are affected with FLUTD, and it remains a frequently encountered problem in small animal veterinary practices nationwide. A variety of treatment options exist for patients with FLUTD, many of which may be combined for optimal effectiveness. These include behavioral modification, dietary changes, medical management, and surgery. Successful therapy for this disorder involves a reduction in the pain, severity, and frequency of clinical signs, and can be achieved through a highly individudualized and adaptable treatment regimen.