A ten-year-old male castrated German shepherd dog was presented to the Cornell Dermatology Service for evaluation of generalized, pruritic seborrhea. The dog had a five-year history of generalized dermatitis as well as poor body condition despite a good appetite, and chronic, intermittent diarrhea. On physical examination, the dog had a body condition score of 2/9 and generalized seborrheic dermatitis and hypotrichosis. Skin cytology was consistent with bacterial folliculitis. Ancillary testing revealed low serum cobalamin and a trypsin-like immunoreactivity (TLI) within the normal reference range. Although these findings are atypical with the classic presentation of exocrine pancreatic insufficiency, the patient's clinical presentation was suggestive of this condition and empiric therapy was elected. Treatment with cefpodoxime, subcutaneous cobalamin, and powdered pancreatic enzymes improved the patient's clinical signs. Upon reexamination one month later, the dog had an improved body condition score of 3/9, and his dermatological lesions and gastrointestinal symptoms had resolved.