This dissertation examines the emergence of posthumanist approaches to memory in contemporary Latin American fiction. Drawing from memory studies, fiction theory, animal studies, and critical posthumanities, it proposes a transregional genealogy based on a twofold move. First, it revisits the essayistic and fictional work of Mexican writer Salvador Elizondo from the 1960s and 1970s, aiming to reassess his place in Mexican literary history while engaging with the philosophical complexity of his interventions in anthropology, cultural graphology, media theory, and animal studies. Second, it turns to works from contemporary Mexico, the Southern Cone, and the continental Caribbean to trace various configurations of what this dissertation terms “posthumanist memory” in Latin American literature. The project considers the legacy of Adolfo Bioy Casares’s La invención de Morel (1940) and its fusion of media theory and the analysis of technical images, which sets the stage for a transhumanist conception of the island as a site of mnemological utopianism in José Urriola’s Santiago se va (2015). Following the thread of Bioy Casares’s hypertextuality, the dissertation then explores the imagination of cyborg authorship in the works of Carmen Boullosa and Rodrigo Fresán, focusing on Boullosa’s La novela perfecta (2006) and Fresán’s Vidas de santos (1993). By addressing the problem of cyborg authorship in terms of what it defines as “artisanal nostalgia,” the dissertation examines how posthumanist approaches to memory challenge Latin American literature to rethink its self-conception in light of digital technologies and emerging modes of remembering. It argues that these literary responses articulate the possibility of posthuman subjectivities shaped by the formal assimilation of memory into narrative, as it discusses new ways of imagining the place of literature within contemporary media ecologies.