Kayla, a 7 year old, female spayed, blue merle, Shetland sheepdog presented to the oncology service at Cornell University's Companion Animal Hospital on 6/6/05 for treatment of an oral papillary squamous cell carcinoma. After an appropriate work-up was completed, a bilateral rostral mandibulectomy was performed. This paper describes the appropriate work-up, surgical procedure and complications, using a clinical case as a model.