Canaliculitis is a rare lacrimal disorder often caused by Streptococcus species, Staphylococcus species, or Actinomyces. In cases associated with punctal plugs, Pseudomonas species are often implicated. Fungal etiology of canaliculitis has been exceedingly uncommon. We present the first report of canaliculitis secondary to Scedosporium, a group of filamentous fungi containing the 2 medically pathogenic species Scedosporium prolificans and Scedosporium apiospermum. Scedosporium spp. are found in soil and water and often infect immunocompromised hosts. The patient responded to punctoplasty with curettage, topical voriconazole, and systemic azole therapy. To the best of the authors' knowledge, there have been no reported cases of fungal canaliculitis due to Scedosporium spp. The collection and evaluation of protected patient health information was Health Insurance Portability and Accountability Act compliant. This report adhered to the tenets of the Declaration of Helsinki as amended in 2013.