A 4-year-old male intact llama presented for a two-month history of scrotal swelling and a one month history of abdominal distension. On physical exam the abdomen was taut and distended, and the animal was in poor body condition. Abdominal ultrasound revealed multiple large fluid-filled structures, displacing the gastrointestinal tract dorsally. Abdominal fluid was drained via an indwelling thoracocentesis tube, and later the cysts were surgically excised. The cysts were serosal in origin, though etiology was unknown as there was no indication of neoplasia or infection. Four months post-excision the animal has an adequate appetite, is in good body condition and had no signs of abdominal distension or scrotal swelling. Abdominal serosal cysts have not been previously described in llamas, and are a possible differential for animals with abdominal distension.