Natural load-bearing structures are characterized by aspects of specialized morphology, lightweight, adaptability, and a regenerative life cycle. PolyBrick 2.0 aims to learn from and apply these characteristics in the pursuit of revitalizing ceramic load-bearing structures. For this, algorithmic design processes and toolset are developed to generate PolyBrick geometries that can be applied to various architectural typologies. The physical manifestations are realized through available clay/porcelain additive manufacturing technologies (AMT). To evaluate the effectiveness, comparative frameworks for digital and physical performance analyses are outlined. Responding to increasing urgencies of material efficiency and environmental sensibility, this project strives to provide for designers a toolset for environmentally responsive, case-specific design, characterized by the embedded control qualities derived from the bone and its adaptability to specific loading conditions. Various approaches to brick tessellation and assembly are also proposed and architectural possibilities are presented. As an outcome of this research, PolyBrick 2.0 is effectively established as a Grasshopper plug-in, “PolyBrick” to be further explored by designers.