This thesis reported on the chemical attachment of a new photochromic organic molecule onto cotton fabrics. The photochromic molecule used in this study is a type of Donor- Acceptor Stenhouse Adducts (DASA) that switches color when exposed to visible light/heat. The attachment process included two steps: (1). Modification of cotton with N, N-methyl(2-bromo-ethyl) ammonium bromide to generate a secondary amine functionality in the cotton fabrics; and (2). Ring opening of the activated furfural in 5- (furan-2-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione by the modified cotton fabrics. These two steps allowed the formation of DASA molecules on the surface of the cotton fabric. The DASA-modified cotton fabrics can change color from pink to colorless when exposed to liquid water, and they return from colorless to pink when heated. This is the first time that this type of DASA molecule is immobilized onto a solid substrate without losing functionality. The modified fabrics can be used as sensors or made into clothes that can respond to visible light, water, and heat.