Previous studies have found that women have richer and more relational autobiographical memories than men. Moreover, COVID-19, as a major public event, has been shown to dramatically change the structure of people’s daily lives and affect their memories (Brown, 2021). Therefore, the present study is interested in how gender differences affect the recall of personal experiences during a pandemic. By coding the personal memories of 194 U.S. participants and analyzing them using One-way ANOVA and Chi-square tests, the researcher found that the differences in emotional expression, memory capacity, and specificity between genders during the pandemic were not significant. Additionally, although social focus between genders was no significant, women’s autobiographical memories continued to be more inclined to recall social events than men’s. In contrast, men were more likely than women to recall personal events. These findings emphasize gender differences in autobiographical memory during the COVID-19 pandemic and have important implications for mental health interventions and well-being enhancement.