Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable and FDA-approved material, widely used in drug delivery. Initiating water vibrations using near-infrared (NIR) light within PLGA microparticles enables remote, accurate control over the release of payload through the localized heating of the polymer matrix. This approach holds significant potential for advancements in targeted drug delivery and photothermal therapies. Confined water, behaving distinctively from bulk with decreased density and specific heat along with higher heat of desorption, is crucial to the localized heating of PLGA particles. This investigation focuses on how confined water's temperature within PLGA microparticles responds to NIR laser stimulation at 980nm, which is absorbed by water. Experiments show PLGA particles experience a temperature increase of 10-30°C, with only a 1°C rise in the bulk environment. However, the temperature response of the confined water remains indeterminate, indicating a need for further investigation into the precise mechanisms of localized heating.