This dataset lists the vascular plants found in a region of central New York State extending from 42 N to 43 N, and 76 W to 77 W (the USGS "Cayuga Quadrangle"), plus a small area north of 43 degrees in the "Cayuga Lake Basin" of early published floras. This multi-county area extends from the Pennsylvania border to north of the Finger Lakes, and from Seneca Lake eastward to just west of Binghamton. Native plant species and species not native to the region are differentiated. Based on comparison of 4 floras from the region, the year by which each non-native species had first established in the Cayuga Region is given (1886, 1926, 1949, or 2005). For species no longer found in the region, the date of the flora by which they had disappeared is given. Also listed for each species are habitat (forest, wet, and open), frequency (rare to common), and for non-natives, their region of origin, and whether they escaped from cultivation.