Lawsonia intracellularis is commonly associated with a disease of swine. L. intracellularis affects a wider range of species than just swine. It is an increasingly diagnosed disease in equines. It primarily affects weanlings from ages three to six months. Common clinical signs are depression, rapid and severe weight loss, diarrhea, colic and subcutaneous edema. Grossly the bacterium causes a proliferative enteropathy involving the entire small intestine. Treatment involves supportive therapy along with antibiotics such as chloramphenicol, oxytetracycline, or erythromycin alone or in combination with rifampin.