Interpretation in public gardens plays a critical role in shaping how visitors understand relationships between plants, people, and place, yet there is limited guidance on how to meaningfully integrate Indigenous perspectives and collaboration into interpretive practice. Existing scholarship outlines key ethical principles, such as reciprocity, consent, and Indigenous data sovereignty, but often does not address how these values are implemented within the constraints of public garden institutions. This capstone project responds to this gap through three interconnected components that move from theory to practice. First, a literature-based framework synthesizes existing scholarship and Indigenous methodologies into a public garden-specific guide for respectful collaboration, outlining key considerations for institutional preparation, relationship-building, and reciprocity. Second, a qualitative study based on interviews with public garden professionals and Indigenous collaborators explores how these principles are applied in practice, highlighting the importance of trust-building, shared authority, and institutional readiness, as well as challenges related to capacity, timelines, and structural support. Third, these insights are applied through the development of an Indigenous Interpretive Master Plan for Cornell Botanic Gardens, which provides a site-specific assessment, goals, and strategies for embedding Indigenous collaboration into interpretation and institutional practice over time. Together, these components demonstrate that effective Indigenous interpretation depends on sustained relationships, structural commitments, and the integration of collaborative values into everyday institutional work. This project positions interpretation as the public expression of these relationships and offers a scalable approach for public gardens seeking to move beyond acknowledgment toward meaningful, reciprocal engagement.