A 12 year old female spayed mixed breed dog was treated at the Cornell University Hospital for Animals for a nasal carcinoma. Due to advanced local disease including invasion of the orbit, cribriform plate, and hard palate, a course of palliative radiation therapy was pursued. The patient experienced acute radiation side effects, necessitating additional hospitalization. The patient returned regularly for follow-up appointments, and eight months after her last radiation treatment, the patient passed away.