Now showing items 7-8 of 8

    • Targeted Therapies: Adaptive Sequential Designs For Subgroup Selection In Clinical Trials 

      Magnusson, Baldur (2011-01-31)
      A critical part of clinical trials in drug development is the analysis of treatment efficacy in patient subgroups (subpopulations). Due to multiplicity and the small sample sizes involved, this analysis presents substantial ...
    • Topics In Bivariate Spline Smoothing 

      Xiao, Luo (2012-08-20)
      Penalized spline methods have been popular since the work of Eilers and Marx (1996). Recent years saw extensive theoretical studies and a wide range of applications of penalized splines. In this dissertation, we consider ...