Now showing items 1-8 of 8

    • Approximate Dynamic Programming Policies And Performance Bounds For Ambulance Redeployment 

      Maxwell, Matthew (2011-05-31)
      Ambulance redeployment is the practice of dynamically relocating idle ambulances based upon real-time information to reduce expected response times for future emergency calls. Ambulance redeployment performance is often ...
    • Aspects Of Penalized Splines 

      Li, Yingxing (2011-01-31)
      Penalized splines approach has very important applications in statistics. The idea is to fit the unknown regression mean using a high-dimensional spline basis, subject to penalization on the roughness. Such an approach ...
    • Hierarchical adaptive regression kernels for regression with functional predictors 

      Woodard, Dawn B.; Crainiceanu, Ciprian; Ruppert, David (2011-01-11)
      We propose a new method for regression using a parsimonious and scientifically interpretable representation of functional predictors. Our approach is designed for data that exhibit features such as spikes, dips, and ...
    • Latent factor regression models for grouped outcomes 

      Woodard, Dawn; Love, Tanzy; Thurston, Sally; Ruppert, David; Sathyanarayana, Sheela; Swan, Shanna (2012-01-31)
      We consider models for the effect of exposure on multiple outcomes, where the outcomes are nested in domains. We show that random effect models for this nested situation fit into a standard factor model framework, which ...
    • On Generalized Additive Models For Regression With Functional Data 

      McLean, Mathew (2013-08-19)
      The focus of this dissertation is the introduction of the functional generalized additive model (FGAM), a novel regression model for association studies between a scalar response and a functional predictor. The FGAM extends ...
    • On The Modeling Of Multiple Functional Outcomes With Spatially Heterogeneous Shape Characteristics 

      Soiaporn, Kunlaya (2014-01-27)
      This dissertation presents an approach for analyzing functional data with multiple outcomes that exhibits spatially heterogeneous shape characteristics. An example of data of this type that motivated this study is a data ...
    • Targeted Therapies: Adaptive Sequential Designs For Subgroup Selection In Clinical Trials 

      Magnusson, Baldur (2011-01-31)
      A critical part of clinical trials in drug development is the analysis of treatment efficacy in patient subgroups (subpopulations). Due to multiplicity and the small sample sizes involved, this analysis presents substantial ...
    • Topics In Bivariate Spline Smoothing 

      Xiao, Luo (2012-08-20)
      Penalized spline methods have been popular since the work of Eilers and Marx (1996). Recent years saw extensive theoretical studies and a wide range of applications of penalized splines. In this dissertation, we consider ...