Barbara Strupp
Professor
2008
NS CALS

Web Bio Page

Current Activities

Current Professional Activities

Cornell University Graduate Field Membership: Psychology; Nutrition; Environmental Toxicology

Editorial Board, Neurotoxicology and Teratology

External Advisory Committee, NIH Program Project grant concerning the Cognitive and Neural Effects of Early Developmental Iron Deficiency; Center for Human Growth and Development, University of Michigan, B. Lozoff, PI, 2003-2013.

Neurobehavioral Teratology Society, Council Member





Current Research Activities
(1) efficacy of perinatal choline supplementation in ameliorating cognitive and neural dysfunction in a mouse model of Down syndrome and Alzheimer's Disease; (2) Study of the efficacy of Succimer, a new chelating agent, in reducing lead-induced neurotoxicity; and (3) role of folate status in cognitive functioning,


Biography

Biographical Statement
I have several ongoing studies in my lab that deal with developmental cognitive disorders, studies that involve both children and rodent models. The goals of the animal studies are to determine the nature and underlying neural basis of the cognitive dysfunction, with implications for therapeutic intervention and for elucidating basic brain-cognition relationships. Four ongoing research projects concern, respectively, prenatal cocaine exposure, early postnatal lead exposure, and mouse models of Down syndrome and Fragile X syndrome. In the latter three projects we are also testing potential interventions. In the case of early lead exposure we are assessing the efficacy of the chelating agent, succimer, to lessen lead-induced cognitive deficits. In the research involving a mouse model of Down syndrome, we are planning to assess the ability to choline supplementation to improve cognitive functioning. In addition, I am just beginning two collaborative projects that focus on the cognitive effects of nutrient alterations during early development. One project is designed to assess the lasting effects of early iron supplementation on cognitive and affective development in children in Africa at high risk for anemia. The second project is designed to assess the effects of altered folate status -- due to both nutrition and genetics -- on cognitive functions dependent on neurogenesis. This project may inform recommendations about optimal folate intake to optimize early brain development and lessen aging-related cognitive decline.

Education
  • Ph.D. 1982 - Cornell University, Biopsychology
  • B.A. 1976 - Washington University, Ethology


  • Courses, Websites, Pubs

    Courses Taught


    NS 703, Fall 2007-present, every semester




    Related Websites

    Psychology Web Page

    Program in Neuroscience

    Institute of Comparative and Environmental Toxicology (ICET) Graduate Field of Environmental Toxicology



    Selected Publications

    Gendle MH, Strawderman M, Mactutus CF, Levitsky DA, Booze RM, and Strupp BJ. Alterations in reactivity to errors and sustained attention in an animal model of prenatal cocaine exposure. Developmental Brain Research, 147, 2003, 85-96 (Special Edition on Drugs of Abuse, invited contribution).


    Stangle, DE., Strawderman M, Smith D., Kuypers M, & Strupp BJ.  Repeated regimens of Succimer show different treatment efficacy in brain versus blood in a rodent model of childhood lead exposure, Environmental Health Perspectives, 112:302-308, 2004 (online, Oct. 31, 2003).


    Gendle MH, White TL, Strawderman M, Mactutus CF, Booze RM, Levitsky DA, and Strupp BJ. Enduring Effects of Prenatal Cocaine Exposure on Selective Attention and Reactivity to Errors: Evidence from an Animal Model. Behavioral Neuroscience, 118(2): 290-297, 2004.


    Driscoll LL; Carroll JC; Moon J-S; Crnic LS, Levitsky DA; Strupp BJ. Impaired Sustained attention and error-induced stereotypy in the aged Ts65Dn mouse, a mouse model of Down syndrome and Alzheimer disease. Behavioral Neuroscience, 2004, 118 (6): 1196–1205.


    Strupp BJ & Beaudin S.  Assessing the neurobehavioral effects of early toxicant exposure: A perspective from animal research. In: Bellinger D (ed.), Human Developmental Neurotoxicology, New York, NY: Taylor & Francis Group, 2006: 415-445. 


    Moon J, Beaudin AE, Crnic L, Levitsky, DA, Strupp BJ. Impairments in inhibitory control, arousal regulation and sustained attention in the fmr1 mouse model of Fragile X syndrome. Behavioral Neuroscience, 2006 Dec;120(6):1367-79.


    Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B; International Child Development Steering Group. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007 Jan; 369(9555):60-70.


    Stangle DE, Smith D, Beaudin SA, Strawderman MS, Levitsky DA, and Strupp BJ.  Succimer chelation improves cognition and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.  Environ Health Perspect. 2007 Feb;115(2):201-9. Epub 2006 Oct 30.


    Beaudin SA, Stangle DE., Strawderman M, Levitsky, DA, and Strupp BJ.  Succimer chelation normalizes emotion regulation in rats exposed to lead early in life:  Evidence from an olfactory conditional discrimination task with periodic omission of an expected reward. Neurotox. Teratol 29: 188–202 (2007) [Online 12 November 2006].


    McNaughton, C. H.,  Moon, J., Strawderman, M. S., Maclean K. N., Evans, J., Strupp, B. J. (2008). Evidence for social anxiety and impaired social cognition in a mouse model of Fragile X syndrome. Behav. Neurosci, 2008 Apr;122(2):293-300.


    Moon J, Ota KT, Driscoll LL, Levitsky DA, Strupp BJ (2008).  A mouse model of Fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies.  Developmental Psychobiology, 2008 Jul;50(5):473-85

     

    Bushnell PJ, Strupp BJ.  Assessing Attention in Rodents. In: Buccafusco J (Ed.), Methods of Behavior Analysis in Neuroscience, 2nd Edition. New York, NY: Taylor & Francis Group, 2008.


    Beaudin SA, Gendle MH, Strupp BJ. Lasting attentional and affective dysfunction produced by prenatal cocaine exposure in a rodent model: Gender effects.  In: Gender Differences in Effects of Prenatal Substance Exposure", Lisa Kestler and Michael Lewis (Eds), American Psychological Association, in press.