Cornell University Graduate Field Membership: Nutrition
Member of American Society for Nutrition
Member of the American Society for Biochemistry and Molecular Biology
NS 610 - Proteins and Amino Acids - Nutritional Regulation of Mammalian Protein Synthesis and Degradation
NS 632 - Regulation of Macronutrient Metabolism
Dominy,J. E. Jr., Simmons, C.R., Hirschberger, L.L., Hwang, J., Coloso, R.M., Stipanuk, M.H. (2007) Discovery and characterization of a second mammalian thiol dioxygenase: Cysteamine dioxygenase. J. Biol. Chem. 282:25189-25198.
Ueki,
Dominy, J.E., Jr., Hwang, J., and Stipanuk, M.H. (2007) Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. Am. J. Physiol. Endocrinol. Metab. 293:E62-E69.
Stipanuk, M.H., Dominy, J.E. Jr., Lee, J-I., and Coloso, R.M. (2006) Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J. Nutr. 136:1652S-1659S.
Dominy, J.E. Jr., Simmons, C.R., Karplus, P.A., Gehring, A.M., and Stipanuk, M.H. (2006) Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. J. Bacteriol. 188:5561-5569.
Simmons,C.R., Liu, Q., Huang, Q., Hao, Q., Begley, T.P., Karplus, P.A., and Stipanuk, M.H. (2006) Crystal structure of mammalian cysteine dioxygenase: A novel mononuclear iron center for cysteine thiol oxidation. J. Biol. Chem. 281:18723-18733. [Issue cover is CDO structure]
Stipanuk, M.H. and Dominy, J.E. Jr. (2006) Surprising insights that aren't so surprising in the modeling of sulfur amino acid metabolism. Amino Acids 30:251-256.
Dominy, J.E., Hirschberger, L.L., Coloso, R. M., and Stipanuk, M.H. (2006) Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat. Biochem. J. 394:267-273.
Simmons, C.R. Hirschberger, L.L., Machi, M.S., and Stipanuk, M.H. (2006) Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels. Protein Expr. Purif. 47:74-81.
Dominy, J.E., Jr., Hirschberger, L.L., Coloso, R.M., and Stipanuk, M.H. (2006) In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system. Adv. Exp. Biol. Med. 583:37-47.
Coloso, R.M., Hirschberger, L.L. Dominy, J.E. Jr., Lee, J-I., and Stipanuk, M.H. (2006) Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues. Adv. Exp. Biol. 583:25-36.
Lee J.-I., Kang, J., Stipanuk, M.H. (2006) Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Biochem. J. 393:181-190.
Stipanuk MH, JE Dominy Jr, J-I Lee, and RM Coloso (2006) Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J. Nutr. 136:1652S-1659S.
Stipanuk MH, M and
Stipanuk MH (2006) Nutrients: History and definitions. In: Biochemical, Physiological & Molecular Aspects of Human Nutrition (M.H. Stipanuk, ed.), Saunders/Elsevier,
Lewis BA, and MH Stipanuk (2006) Structure, nomenclature, and properties of carbohydrates. In: Biochemical, Physiological & Molecular Aspects of Human Nutrition (M.H. Stipanuk, ed.), Saunders/Elsevier,
Stipanuk MH (2006) Protein and amino acid requirements. In: Biochemical, Physiological & Molecular Aspects of Human Nutrition (M.H. Stipanuk, ed.), Saunders/Elsevier,
Stipanuk MH (2006) Regulation of fuel utilization in response to exercise. In: Biochemical, Physiological & Molecular Aspects of Human Nutrition (M.H. Stipanuk, ed.), Saunders/Elsevier,
Stipanuk MH (2006) Disturbances of energy balance. In: Biochemical, Physiological & Molecular Aspects of Human Nutrition (M.H. Stipanuk, ed.), Saunders/Elsevier,
Stipanuk MH (2006) Transamination. In: McGraw Hill Encyclopedia of Science & Technology, 10th edition, McGraw Hill, pp. 540-543.
Simmons, C.R., Hao, Q., Stipanuk, M.H. (2005) Crystallization and preliminary x-ray analysis of purified recombinant cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 61:1013-1016.
Stipanuk MH (2005) Homocysteine, Cysteine and Taurine. In: Modern Nutrition in Health and Disease, 10th edition, ME Shils, M. Shike, AC Ros, B Caballero, RJ Cousins, eds., pp. 545-562.
Stipanuk, M. H., Hirschberger, L. L., Londono, M. P., Cresenzi, C. L., and Yu, A. F. (2004) The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. Am. J. Physiol. Endocrinol. Metab. 286: E439-E448.
Lee, J.-I., Londono, M. P., Hirschberger, L. L., and Stipanuk, M. H. (2004) Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level. J. Nutr. Biochem. 15: 112-122.
Stipanuk, M. H. Londono, M., Hirschberger, L. L., Wang, L.,and Hickey, C. (2004) Evidence for expression of a single distinct form of mammalian cysteine dioxygenase. Amino Acids 26: 99-106.
Dominy JE and MH Stipanuk (2004) New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutr Rev Sep;62(9):348-353.
Stipanuk MH (2004) Role of the liver in regulation of body cysteine and taurine levels: a brief review. Neurochem. Res. 29:105-110.
Stipanuk MH (2004) Sulfur Amino Acid Metabolism -- Pathways for Production and Removal of Homocysteine and Cystine. Annu. Rev. Nutr. 24:539-577.
Stipanuk MH (2003) Role of the liver in regulation of body cysteine and taurine levels. Neurochem. Res. 29:105-110.
Cresenzi, C. L., Lee, J.-I., and Stipanuk, M. H. (2003) Cysteine is the metabolic signal responsible for dietary regulation of cysteine dioxygenase and glutamate cysteine ligase in vivo. J. Nutr. 133:2697-2702.
Stipanuk, M. H. (2003) Role of the liver in regulation of body cysteine and taurine levels. Neurochem. Res. 29: 105-110.
Stipanuk MH (2003) Nutrients; Sodium; Calorie. In: Encyclopedia of Food (SH Katz, ed.). Charles Scribner's Sons, Vol. 2, pp. 578-588; Vol. 3, pp. 294-297; Vol. 1, pp. 297-298.
Stipanuk MH, M Londono, J-I Lee, M Hu, and AF Yu (2002) Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J. Nutr. 132:3369-3378.
Bella DL, LL Hirschberger, YH Kwon, and MH Stipanuk (2002) Cysteine metabolism in periportal and perivenous hepatocytes: perivenous cells have greater capacity for glutathione production and taurine synthesis but not for cysteine catabolism. Amino Acids 23:453-458.
Kwon, Y.H. and Stipanuk, M.H. 2001. Cysteine regulates cysteine dioxygenase and g-glutamylcysteine synthetase in cultured rat hepatocytes. Am. J. Physiol. 280: E804-E815.
Bella, D.L., Kwon, Y.H., Hirschberger, L.L. and Stipanuk, M. H. 2000. Evidence for the posttranscriptional regulation of cysteine dioxygenase in rat liver. In: Taurine 4: Taurine and Excitable Tissues, L. D. Corte, R. J. Huxtable, G. Sgaragli, and K. F. Tipton, eds., Plenum Press, pp. 71-85.
Ohta, J., Kwon, Y.-H. and Stipanuk, M. H. (2000) Cysteine metabolism by primary cultures of hepatocytes responds to methionine supplementation of the culture medium. Amino Acids 19:705-728.
Hirschberger, L. L., Daval, S., Stover, P. J., and Stipanuk, M. H. (2000) Murine cysteine dioxygenase: structural organization, tissue-specific expression and promoter identification. Gene 277: 153-161.
Stipanuk MH and M Watford (2000) Amino acid metabolism. In: Biochemical and Physiological Bases of Human Nutrition, MH Stipanuk, ed. WB Saunders, pp. 233-286.
Ohta J, Y-H Kwon, and MH Stipanuk (2000) Cysteine dioxygenase and gamma-glutamylcysteine synthetase activities in primary cultured hepatocytes respond to sulfur amino acid supplementation in a reciprocal manner. Amino Acids 19:705-728.
Bella DL, LL Hirschberger, Y Hosokawa, and MH Stipanuk (1999) Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am. J. Physiol. 276 (Endocrinol. Metab. 39):E326-E335.
Stipanuk MH (1999) Homocysteine, cysteine and taurine. In: Modern Nutrition in Health and Disease, 9th ed. (Shils, M. E., et al., eds.), pp. 543-558.
Bella DL, C Hahn, and MH Stipanuk (1999) Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am. J. Physiol. 277 (Endocrinol. Metab. 40):E144-E153.