I started to work in Professor Brenna’s lab in Nutrition Science at May 2006. The research area I am interested and involved in is to investigate the physiological role of long-chain polyunsaturated fatty acids (LCPUFA), especially with respect to early development of the central nervous system and the eye
Polyunsaturated fatty acids are involved in a wide variety of physiological processes. They are particularly critical in the perinatal period when the developing fetus or newborn is forming neural tissue with membranes rich in unsaturated fatty acids. The nutritional supply of certain long chain polyunsaturated fatty acids (LCPUFA) during development is critical.
We are particularly interested in the role of LCPUFA in the nutritional health of premature infants. Their nutritional requirements are ill defined because their survival was very low until the advances in neonatal medicine of the last two decades; thus neither breast milk nor traditional formula can be assumed to meet their needs.
Using primates as models for quantitative requirements of the human brain, we administer tracer doses of essential fatty acids to pregnant primates and analyze fetal tissues to determine levels of accumulation and metabolism. This work has shown that large amounts of essential fatty acids are metabolized in pathways other than those required for essential components of neural tissue, indicating that the role of these fatty acids is more complex and probably even more critical than previously supposed. We have also established the relative efficacy of linolenic acid (C18:3w3) as a precursor to the structurally important docosahexaenoic acid (C22:6w3) in pregnancy and in neonatal baboons.
In addition, many evidence suggest that mitochondra have a central role in aging-related neurodegeneration diseases (Alzheimer's disease, Parkinson's disease). My current research is also focus on the role of mitochondria in neurodegeneration.
In 1977, I graduated from
In 1988, I started to work as a research
assistant for visual development screening and the research of myopia and
amblyopia in Professor Howland at
Ph.D. Physiology (Vision)
in Ophthalmology The