Tong Li
Research Associate,Sr
2007
HENutrSciWeb Bio Page
Current Activities
Current Research Activities
I
started to work in Professor Brenna’s lab in Nutrition Science at May 2006. The
research area I am interested and involved in is to investigate the
physiological role of long-chain polyunsaturated fatty acids (LCPUFA),
especially with respect to early development of the central nervous system and
the eye
Polyunsaturated
fatty acids are involved in a wide variety of physiological processes. They are
particularly critical in the perinatal period when the developing fetus or
newborn is forming neural tissue with membranes rich in unsaturated fatty
acids. The nutritional supply of certain long chain polyunsaturated fatty acids
(LCPUFA) during development is critical.
We are particularly interested in the role of LCPUFA in the nutritional health
of premature infants. Their nutritional requirements are ill defined because
their survival was very low until the advances in neonatal medicine of the last
two decades; thus neither breast milk nor traditional formula can be assumed to
meet their needs.
Using primates as models for quantitative requirements of the human
brain, we administer tracer doses of essential fatty acids to pregnant
primates and analyze fetal tissues to determine levels of accumulation and
metabolism. This work has shown that large amounts of essential fatty acids are
metabolized in pathways other than those required for essential components of
neural tissue, indicating that the role of these fatty acids is more complex
and probably even more critical than previously supposed. We have also
established the relative efficacy of linolenic acid (C18:3w3) as a precursor to
the structurally important docosahexaenoic acid (C22:6w3) in pregnancy and in
neonatal baboons.
In addition, many evidence suggest that mitochondra have a central role in aging-related neurodegeneration diseases (Alzheimer's disease, Parkinson's disease). My current research is also focus on the role of mitochondria in neurodegeneration.
Biography
Biographical Statement
In 1977, I graduated from Harbin Medical
School in China. As a resident, I worked in the ophthalmology
department of The First Harbin Hospital in Harbin until 1982. I started my graduated (in Ophthalmology) study
at Harbin
medical school. The research focused on the
mechanism of immune ophthalmitis, the effects of lysosome enzymes on immune ophthalmitis. In 1984, I worked as an ophthalmologist in the
ophthalmology department of the Second Teaching Hospital of Harbin Medical
School doing routine clinical practice in both in-patient and out-patient
departments, and teaching, instructing the medical school students. In 1985, I was promoted to be an ophthalmologist-in-charge
until I left the hospital for US
in1988.
In 1988, I started to work as a research
assistant for visual development screening and the research of myopia and
amblyopia in Professor Howland at Cornell
University. In 1990, I registered as a PhD graduate
student in physiology department of veterinary medicine in Cornell
university. My research is on regulation
of the eye growth, the effects
of constant light on the development of the chick eye, including the effects of
darkness and strength of diurnal lightening rhythm on light-induced changes in
the chick eyes, the modulation of constant light effects on the chick eyes by
ciliary ganglionectomy and optic nerve section and consensual pupillary
response in chicks. After my PhD study, I
continued to study on the circadian rhythm of the eyes and ocular development,
working on animal model to investigate the effects of melatonin, dopamine and
pineal gland on the growing as a postdoctoral, research associate, senior
research associate in the department of neurobiology and Behavior, Cornell University. In
2006, I started to work in professor Tom Brenna’s Lab at Nutrition Science
of Cornell University.
Education
Postdoctoral
Associate (Neurobiology) Cornell University, Ithaca,
NY 1996
- 1999
Ph.D. Physiology (Vision) Cornell
University, Ithaca, NY 1990 - 1996
M.
S. Ophthalmology Harbin
Medical School,
Harbin, China 1982 - 1984
Resident
in Ophthalmology The Harbin First
Hospital, Harbin, China 1977 - 1981
M.
D. Medicine Harbin Medical School, China 1973 - 1977
Courses, Websites, Pubs
Publications
Li, T. & H.C. Howland (2006) Role of the pineal gland in ocular
development of the chick under normal and constant light conditions. Invest. Ophthalmol. Vis. Sci. Vol. 47, (11) 5132-5136