Rinderpest is a morbillivirus that affects many arteriodactyls, particularly cattle, Cape buffalo (Syncerus caffer), lesser kudu (Tragelaphus imberbis) and eland (Taurotragus oryx). Designated by the Office Internationals des Epizooties (OIE) as a Class A disease, it has many world trade ramifications. It presently exists in regions of India, the Middle East and Eastern Africa, where there was a wildlife epidemic between 1993 and 1997. The disease is spread by direct or close contact of aerosolized virus, and epitheliotrophic clinical signs are observed. Diagnosis is achieved at necropsy or through use of serological screening tests including ELISA, virus neutralization and immunoflourescence. In the 1990's a wildlife epidemiosurveillance network was established to investigate and control rinderpest in Eastern Africa, including Kenya, Uganda, Tanzania and Ethiopia. Many wildlife species were immobilized for serological sampling. The epidemic zone was determined in Kenya and prevalence of rinderpest in buffalo during the 1993-1997 epidemic was calculated at 95%. A minimum sampling fraction of 2% during an epidemic was determined. This project established a permanent serosurveillance network and results carried many epidemiological implications for rinderpest monitoring and control.